Strategy of insomnia treatment in patients with chronic cerebral ischemia and comorbid pathology
ARTICLE PDF (Українська)


chronic cerebral ischemia, small vessels disease, insomnia

How to Cite

Sulik, R., Klymenko, O., Yavorska, A., Kovbasyuk, Y., & Klymenko, L. (2018). Strategy of insomnia treatment in patients with chronic cerebral ischemia and comorbid pathology. East European Journal of Neurology, (2(20), 4-11.


The article presents the results of rofen drug study effectiveness in the treatment of patients with chronic cerebral ischemia with insomnia. The characteristic of vegetative and objective complaints regressions in patients during the treatment is presented. The effectiveness of different treatment regimens is evaluated depending on the duration of anxiety-depressive disorders and autonomic dysfunction. The influence of the duration of insomnia, comorbidity, anxiety-depressive disorders on the choice of therapeutic tactics in this patient has been analyzed.
ARTICLE PDF (Українська)


1. Murashko, N.K., Sulik R.V. (2011). Chronic cerebrovascular accident: emphasis on diagnosis and treatment. Medications of Ukraine, №9 (155), 58-63.
2. Orestes, F.V., Breno, D.S., Antonio, T.L., Florindo, S., Wagner, G. (2013). Mild cognitive impairment (part 2): biological markers for diagnosis and prediction of dementia in Alzheimer’s disease. Rev. Bras. Psiquiatr. № 35(3), 284–294.
3. Levin, Y.I., Poluektov, M.G. (Ed.). (2013). Somnology and medicine sleep. Selected lectures. M: Medforum.
4. Cappuccio, F.P., Taggart, F.M., Kandala, N.-B. et al. (2008) Meta-analysis of short sleep duration and obesity in children, adolescents and adults. Sleep. (31), 619–26.
5. Schmid, S.M., Hallschmid, M., Jauch-Chara, K. et al. (2005). Association of sleep time with diabetes mellitus and impaired glucose tolerance. Arch Intern Med. (165), 863–7.
6. Knutson, E., Van Cauter, P., Zee, K.L., Lauderdale, D.S. (2011). Cross-Sectional Associations Between Measures of Sleep and Markers of Glucose Metabolism Among Subjects With and Without Diabetes: The Coronary Artery Risk Development in Young Adults (CARDIA) Sleep Study. Diabetes Care. (34), 1171.
7. Cappuccio, F.P., Stranges, S., Kandala, N.-B. et al. (2007). Gender-specific associations of short sleep duration with prevalent and incident hypertension. The Whitehall II Study. Hypertension. (50), 694–701.
8. Meng, L., Zheng, Y., Hui, R. (2013). The relationship of sleep duration and insomnia to risk of hypertension incidence: a meta-analysis of prospective cohort studies. Hypertens Res., № 36(11), 985-95.
9. Laugsand, L.E., Strand, L.B., Platou, C., Vatten, L.J. and Janszky, I. (2013) Insomnia and the risk of incident heart failure: apopulation study. European Heart Journal, 1-12. Retrieved from
10. Baglioni, C., Battagliese, G., Feige, B., Spiegelhalder, K., Nissen, C., Voderholzer, U., Lombardo, C., Riemann, D. (2011). Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. J. Affect Disord., №135(1-3), 10-9.
11. Floam, S., Simpson, N., Nemeth, E., Scott-Sutherland, J., Gautam, S., Haack, M. (2015). Sleep characteristics as predictor variables of stress systems markers in insomnia disorder. Journal of Sleep Research., № 24 (3), 296–304.
12. Wayne A.M., Hecht K. (1989). The dream of man. Physiology and pathology. M: Medicine.
13. Murashko, N.K., Sulik R.V. (2012). Stenotic and occlusive lesions of brachiocephalic and vertebral arteries. Medications of Ukraine, №3-4 (2), 54-58.
14. Spiegel, K., Tasali, E., Penev, P. (2004). Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann. Intern. Med., 141, 846—850.
15. Carroll, J.E., Seeman, T.E., Olmstead, R., Melendez, G., Sadakane, R., Bootzin, R., Nicassio, P., Irwin, M.R. (2015). Improved sleep quality in older adults with insomnia reduces biomarkers of disease risk: Pilot results from a randomized controlled comparative efficacy trial. Psychoneuroendocrinology, 55, 184–192.