Atherosclerotic cardiovascular disease is the leading cause of mortality worldwide. Evidence suggests that the risk of atherosclerosis complications associated not only with local changes within atherosclerotic plaque (such as the state necrotic core or fibrous cap), but also with the state of blood or systemic factors. Circulating levels of cytokines, prothrombotic factors or acute phase reactants may play a role in the occurrence of acute stroke in the presence of affected vessels, even in the absence of stenosis. For example, increased serum biomarkers such as C-reactive protein, cytokines - predict the progression of atherosclerosis and risk of stroke. Stroke, may be caused by atherosclerosis of large arteries supplying the brain, or it may affect smaller branches inside the skull.
2. Koliesnikova I.E. Pharmacological correction of experimental mitochondrial dysfunction of brain stem neurons by rhytmocor and mildronat / Koliesnikova I.E., Nosar V.I. // Fiziol Zh. – 2013. – Vol. 59 (3). – P. 58-64.
3. Barquera S. Global Overview of the Epidemiology of Atherosclerotic Cardiovascular Disease / Barquera S., Pedroza-Tobias A. // Arch Med Res. – 2015. – Vol. 46 (5). – P. 328-338.
4. Krishnamurthi RV1. Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990-2010: findings from the Global Burden of Disease Study 2010 / Krishnamurthi RV1, Feigin VL2, Forouzanfar MH. // Lancet Glob Health. – 2013. – Vol. 1 (5). – P. 259-281.
5. Bennett DA1. The global burden of ischemic stroke: findings of the GBD 2010 study / Bennett DA1, Krishnamurthi RV2, Barker-Collo S. // Glob Heart. – 2014. – Vol. 9 (1). – P. 107-112.
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