Multiple sclerosis (MS) – a chronic inflammatory demyelinating disease of an infectious-allergic origin, which begins mostly in young age, affects mainly female subjects, manifests itself as signs of a multifocal lesion of the central nervous system, has a remitting, less progressive nature of the course, often.leads to disability. Aim: to analyze the clinical and demographic characteristics of patients with MS in the aspect of comorbidity. We examined 216 patients with MS with different types of course. The patients with MS of the general sample were divided into 2 groups: without concomitant diseases (WCD,n = 109) and with the presence of concomitant diseases (PCD, n = 107). A detailed analysis of the clinical anddemographic characteristics of patients with MS in the aspect of comorbidity (WCD and PCD groups) was conducted. Gender differences in gender differences were insignificant (p> 0.05) when analyzing WCD and PCD groups according to age, gender characteristics,duration of MS and its course, while differences in age and clinical features of the disease were found to be emphasized deeper manifestations of MS in patients with PCD group. From the obtained data, it follows that in the PCD group there is a significant increase in the frequency of comorbidity in the course of MS, and the concomitant pathology in MS in the PCD group was significantly more common in patients with a PC duration of 11 years or more.