Today, in medical practice, the number of patients who for a long time with the development of acute or chronic pain syndrome are forced to use non-steroidal anti-inflammatory drugs (NSAIDs) is steadily growing. At present, the problem of the relative cardiovascular safety of NSAID use is topical, which causes serious concern in the treatment of patients with severe vascular comorbidity. The safe use of NSAIDs, especially among elderly patients who may be at high risk for CVD or adverse gastrointestinal (GI) complications, is a constant problem for the doctor. Although the results of PRECISION provide an overview of the overall safety of these NSAIDs, the conclusions about the relative safety of celecoxib, naproxen and ibuprofen are complex and represent remaining gaps in knowledge. In a low-risk population in which the majority of patients received treatment for risk reduction, the data indicate that short-term CRs associated with all three drugs are really low and similar. There remains an open question about the effect of the duration of treatment and the dose of NSAIDs on the risk of cardiovascular disease. The meta-analysis did not reveal an increased risk of NSAIDs when used for less than 30 days or less than in full doses. It is recommended to evaluate the use of NSAIDs in patients based on individual risk factors to optimize the balance between anti-inflammatory and potential adverse events.
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https://scholar.google.com.ua/citationsuser=M0m9l3gAAAAJ&hl=uk#d=gs_md_citad&p=&u=%2Fcitations%3Fview_op%3Dview_citation%26hl%3Duk%26user%3DM0m9l3gAAAAJ%26citation_for_view%3DM0m9l3gAAAAJ%3AYsMSGLbcyi4C%26tzom%3D-120 [in Ukrainian]
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