Features of the relationship between blood pressure and endothelial vasomotor function of the initial manifestations of chronic brain ischemia patients
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Treschinskaya, M., Golovchenko, Y., Ryabichenko, T., Klyuchnikova, O., Belska, I., & Kurochkin, I. (2016). Features of the relationship between blood pressure and endothelial vasomotor function of the initial manifestations of chronic brain ischemia patients. East European Journal of Neurology, (4(10), 44-49. https://doi.org/10.33444/2411-5797.2016.4(10).44-49


Introduction. Cerebrovascular pathology in all its manifestations (acute ischemic stroke and chronic cerebral ischemia) leads to significant mortality and disability in the population in our country. Arterial hypertension (AH) is one of the main factors of cardiovascular risk of chronic cerebral ischemia (ChCI). We carried out a study whose purpose was to assess the state density and the nature of relationships between indicators AP monitoring (DAPM) and biochemical indices of endothelial vasomotor function in patients with initial manifestations of ChCI.

Material and methods. We examined 116 patients with initial manifestations of ChCI. All patients underwent general-clinical, clinical and neurological, neuroimaging, clinical and laboratory examination, including the determination of biochemical markers of vasomotor endothelial dysfunction (endothelin-1 (ET-1) and nitrite) and compression test to assess flow-mediated dilation (FMD).

Results and its discussion. Percentage (FMD obtained during cuff trials statistically significantly correlated with mean PAT day (r = -0,306, p = 0,002) and an average PAP night (r = -0,327, p = 0,001). Tight linkage was observed between the level of ET-1 and indicators of blood pressure variability, thus mainly at night (SBP, DBP, ABP, PBP). The level of nitrite was mainly associated with blood pressure load index. A sufficiently high density of association (by Cramer's V=0,419-0,566) points to the clinical significance of the relative risk of rejection nitrite levels beyond the norms (the development of endothelial dysfunction) by increasing the load systolic and diastolic blood pressure and systolic blood pressure during the day at night.

Conclusions. It was found that the increase in PAP in active and passive during the day has been associated with the development of vasomotor ED. It was found that increased levels of ET-1 was accompanied by an increase in the variability of systolic blood pressure during the day and at night, diastolic blood pressure, SBP and DBP at night. There was a trend to an increase in systolic blood pressure load due to lower levels of nitrite. Sufficient density of associative links point to the trend towards the development of vasomotor ED with increasing load systolic blood pressure during the day and at night.

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1. Aird W.C. 2007. Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. Circulation Research. 100 (2): 158–173.
2. Celermajer, D.S. 1992. Noninvasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis / D.S. Celermajer, K. E. Sorensen, V. M. Goochetal. Lancet.340:1111-1115.
3. Davignon J., Ganz P. 2004. Role of Endothelial Dysfunction in Atherosclerosis. Circulation. 109: 27-32.
4. Goff, D. C., Lloyd-Jones, D. M., Bennett, G., Coady, S., D’Agostino, R. B., Gibbons, R. et. al (2013). 2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk.Circulation, 129 (25), S49–S73.doi: 10.1161/01.cir.0000437741.48606.98
5. Green D. 2005. Point: flow-mediated dilation does reflect nitric oxide-mediated endothelial function. J ApplPhysiol. 99: 1233–1234.
6. Hadi, H., Carr, CS., Suwaidi, J. (2005) Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome. Vascular Health and Risk Management, 1(3), 183–198.
7. Harris A.R., Nishiyama S.K., D.W.Wray, R.S. Richardson 2010. Ultrasound Assessmentof Flow-Mediated Dilation. Hypertension. 55: 1075-1085.
8. Head, GA. A novel measure of the power of the morning blood pressure surge from ambulatory blood pressure recordings / GA Head, K Chatzivlastou, EV Lukoshkova, GL Jennings, CM Reid // Am J Hypertens.-2010.- № 23.-Р.1074–1081.
9. Hermida, RC. 2013 ambulatory blood pressure monitoring recommendations for the diagnosis of adult hypertension, assessment of cardiovascular and other hypertension-associated risk, and attainment of therapeutic goals /RC. Hermida, MH. Smolensky, DE. Ayala et al. // Chronobiol Int. – 2013.-№30.-Р.355-410.
10. Kuvin J.T., Karas R.H. 2003. Clinical utility of endothelial function testing: ready for prime time? Circulation. 107(25): 3243-3247.
11. Mancia G., et al., 2013 ESH/ESC Guidelines for the management of arterial hypertension. J. of Hypertension 2013, 31:1281-1357.
12. O’Brien, E. Ambulatory blood pressure measurement: what is the International Consensus? [Text] / E. O’Brien, G. Parati, G. Stergiou //Hypertension.- 2013.- №62.- Р.988– 994.
13. O’Brien, E. European Society of Hypertension position paper on ambulatory blood pressure monitoring / E. O’Brien, G. Parati, G. Stergiou, et al. // J Hypertens.- 2013.-Vol.31.-№9.-P.1731– 1767.
14. Parati, G. European Society of Hypertension practice guidelines for ambulatory blood pressure monitoring / G. Parati, G. Stergiou, E. O’Brien et al. //J Hypertens.- 2014.-№32.-Р.1359-1366.
15. Pretnar Oblak J. 2014. Cerebral Endothelial Function Determined by Cerebrovascular Reactivity to L-Arginine. Bio Med Research International. http://dx.doi.org/10.1155/2014/601515.
16. Rajendran P., Rengarajan T., Thangavel J., Nishigaki Y., Sakthisekaran D., Sethi G., Nishigaki I. 2013.TheVascular Endothelium and Human Diseases. Int. J. Biol. Sci.9(10):1057-1069.